Hypertension, Cardiovascular Diseases
Lisinopril is used for treatment of diseases characterized by high blood pressure (hypertension) in adults and children older than 6 years. The principle of work of this Lisinopril hctz is in the relaxation of the blood vessels, causing them to widen, which may lead to the prevention of occurrence of heart attacks, strokes and kidney problems. Lisinopril hctz is also used by patients after acute myocardial for their recovery, Lisinopril is used together with other medications for treatment of heart failure. This medication belongs to the class of drugs called ACE inhibitors.
The majority of patients, the antihypertensive effect appears in one-two hours after oral administration of Lisinopril, and the maximum – in about six-nine hours. Stabilization of the therapeutic effect is observed in tree-four weeks. The syndrome is not developed. Absorption of the drug after oral administration is approximately 25-50%. Simultaneous eating doesn’t affect the skin.
The maximum concentration in plasma is reached after about 6-7 hours. Lisinopril marginally associated with blood plasma proteins. Lisinopril displayed with urine in an unmodified form.
Half – life period is 12 hours. In case of violation of the kidney excretion of Lisinopril is reduced in proportion to the degree of functional impairment. In patients older age (over 65 years), as well as in heart failure renal clearance Lisinopril reduced. The drug appears in hemodialysis.
- - hypersensitivity to Lisinopril or other components of the preparation;
- - angioedema, including idiopathic and hereditary angioedema;
- - cardiogenic shock;
- - acute myocardial infarction in case of arterial hypotension (systolic blood pressure below 90 mm Hg);
- - period of pregnancy and lactation;
- - up to age 12 years.
- Lisinopril should be taken orally 1 time a day, every day, at the same time. Eating doesn’t affect the absorption of Lisinopril tablets. The dose should be determined individually in accordance with all clinical data of this patient and the response of blood pressure.
- Lisinopril can be used both as a monotherapy and in combination with other antihypertensive drugs.
- As a rule, the initial dose in treatment of arterial hypertension is 5 mg per day in one dose (in the morning). If the blood pressure is normal, the dose is increased up to 10-20 mg (depending on all clinical response of the patient) 1 times a day in the morning. The recommended dose is usually 10 to 20 mg, the maximum is 40 mg in day.
Treatment of acute myocardial infarction should start in the first twenty-four hours of the onset of indications of myocardial infarction (in the absence of arterial hypotension). The initial dose of Lisinopril is 5 mg in day, target dose – Lisinopril 10 mg per day in one dose. Patients with a systolic pressure of not higher than 120 mm Hg, before and during therapy, in the first 3 days after myocardial infarction start treatment in the dose of 2.5mg. At the level of systolic blood pressure below 100 mm Hg therapeutic dose should not exceed 5 mg in day (may be reduced to 2.5 mg). If, after receiving Lisinopril in the dose of 2.5mg level of systolic blood pressure below 90 mm Hg, Lisinopril 20 mg must be discontinued. Recommended duration of myocardial infarction is 6 weeks.
In chronic heart failure initial dose of 2.5mg (half tablet 5 mg). The dose is gradually increased according to the individual response. Recommended target therapeutic dose – Lisinopril 20 mg per day in one dose. Be wary appoint patients who are taking or taking diuretics. If it’s impossible to advance to end the use of diuretics, Lisinopril recommended taking with minimum doses under the control of blood pressure and renal function.
The initial dose in treatment of nephropathy (initial stage) in patients with diabetes mellitus type II is Lisinopril 10 mg 1 time per day, the maximal dose of Lisinopril 20mg 1 time per day. When diabetes (in connection with the possibility of hyperpotassemia) treatment Lisinopril should be started with low doses and should be conducted under the supervision of a physician.
Treatment of kidney failure and creatinine clearance 30-80 ml/min: the initial dosage is 2.5mg 1 time per day in the morning. Therapeutic dose (5-10 mg / day) is dependent on individual patient response. Do not exceed the maximum daily dose of Lisinopril 20mg. If you have kidney failure and creatinine clearance less than 30 ml/min, the recommended initial dose of 2.5mg. Daily dose is determined individually, depending on the sensitivity of it is expedient to increase the interval between meals preparation (1 time in 2 days).
Laboratory and medical tests (e.g., the level of potassium in the blood or kidney function) must be performed periodically to monitor your progress or to identify the drug side effects. Check your blood pressure regularly, taking Lisinopril, in particular, when you first started to take Lisinopril or when the dose is changed.